课程

课程描述

论文 Track 

 Non-Thesis Track 

可打印版本

课程描述

药学基础(PSC 631))
The course reviews the foundational topics in 药理学, pharmaceutics, and 药物化学. 涵盖的主题包括受体-配体相互作用的原理, 剂量响应曲线, 药物动力学(吸收, 分布, 和消除毒品), 结构活性关系, 药效学(药物浓度和效果), 药物的生物转化及影响药物作用的因素, 药物受体相互作用的计算建模原理, 合理的药物设计. (3学分) 先决条件: CHE 312 or PSC 311; PSC 321/322.

研究伦理(610年乙) 
这门课 includes a discussion format based on ethical issues involved in the research process. Students will have focused reading on the ethical issues involved in research and then will apply the readings to 案例研究 during discussion. 涵盖的主题包括, 但不限于:道德和研究伦理, 研究委员会面临的伦理问题, 涉及人类和动物的伦理问题, 研究报告和利益冲突. (1).

实验设计和数据分析(PSC 672) 
这门课 is required for all 医药科学 graduate students and provides students with a basic knowledge of experimental design and biostatistics. 学生将学习如何设计实验和分析结果. 本课程将涵盖单因素实验, 多种因素, 全因子和部分因子设计和筛选设计, 假设检验和相关生物统计学的基础知识. (2学分).

研究轮岗(psc661) 
Students will complete a one semester laboratory rotation in order to facilitate the selection of a thesis research advisor. Students select a potential mentor based on interests and availability of openings in any given lab. 作业, 基于学生的喜好, 将由制药科学研究生项目主任负责吗. Students are expected to spend a minimum of 10 hours per week on laboratory research during the rotation. Students complete a rotation through a minimum of 1 lab and a maximum of 2 labs during the semester. They are to meet with the faculty advisor at least one hour per week for basic introduction to laboratory principles and practices, 并讨论他们的研究. Students are required to complete reading assignments as directed by the faculty advisor and write a report of the research data and present a ten minute talk summarizing their research at the end of the rotation. (2学分).

药学杂志俱乐部(PSC 651) 
这门课, 是所有药学研究生的必修课吗, is designed to enhance the ability of graduate students to critically evaluate scientific articles published in juried scientific journals. Articles will be selected from current scientific literature in a variety of disciplines in the pharmaceutical sciences, 包括给药, 药物开发, 药物化学, 分子生物学, 药物基因组学, 药理学, 生理学, 生物化学与制药. 所有参与者将阅读并评论文章. 每个学生每学期至少要提交两篇文章. (1)

Required courses (6 credits) can be selected from the following list of courses marked with an asterisk.

*生物制药产品的下游加工(PSC 620)
这门课 will serve to introduce students to downstream bioprocessing principles and technologies used in the industry for 净化 of microbial and mammalian biologics along with supporting QC/QA techniques and analyses related to the biopharmaceutical manufacturing to ensure product purity, 身份, 和安全. 本课程将结合讲授和讨论细胞分裂的主要步骤, 分离, 净化, 以及配方技术(均质), 离心分离, 过滤, 色谱法, TFF) used in the 净化 of biologics with hands-on laboratory training and core techniques i.e., electrophoresis, glycan analysis, functional assays, 色谱法, and cell-based assays. 完成课程后, students will demonstrate the ability to understand how biopharmaceuticals are purified and certified safe and effective. (3)

*哺乳动物细胞培养(BIO 631)
哺乳动物细胞培养技术已被常规用于研究, 药物发现, 以及生物制品的生物制造. The Mammalian Cell Culture Course focuses on applications of mammalian cells in the biomanufacturing of value-added products. The course will serve to introduce the students to (1) overview and applications of mammalian cell culture technology, (2)无菌技术及实验室安全和生物安全的重要性, (3)细胞培养基本技术, (4)培养细胞的生物学和特性, (5)细胞系发育与代谢工程原理, (6)细胞培养基设计, 准备, 优化策略, (7)上游分析, (8)放大和生物反应器, (9)监管指引. Students will learn to subculture/passage both adherent and suspension mammalian cells. Students learn adherent cell culture in T-flasks and microcarrier bead technology. Students learn suspension cell culture in shake flasks, spinner flasks, and stir-tank bioreactors. The Mammalian Cell Culture Course is a lab-intensive lecture and discussion-based course. 学生通过积极的学习活动来学习, 比如基于实验室的实验, 案例研究, 演讲, 还有小组辩论. 完成本课程后, students will learn the principles and applications of mammalian cells and the utilization of mammalian cells for the biomanufacturing of safe and effective products.

*规管科学(PSC 646)
监管科学是开发新工具的科学, 安全评估的标准和方法, 功效, 质量, 以及产品的性能, 根据美国FDA的定义. The course begins with introducing the history and current status of the US federal regulatory system and the FDA. 随着课程的进行, 重点将放在法律的结构和结果上, 监管策略, 全球化问题和这一新兴领域的伦理困境, 使用案例和讨论来进行主动学习. (3学分)  先决条件: PSC341 Pharmaceutics I, PSC641 Advanced Pharmaceutics I, or equivalent, and permission of instructor.

*癌症的药理学和分子遗传学(PSC 733)) 
肿瘤发生的分子遗传机制研究, 包括致癌基因的作用, 肿瘤抑制, 病原体(病毒和细菌). Genomic approaches to the study of both hereditary cancers and somatic mutations will be explored. The 药理学 of current cancer therapeutics and the rational design of novel anti-cancer drugs will be discussed throughout the course. (3学分)  先决条件: PSC 631或导师的许可.

*定量药物设计(PSC 757)
The principles of subcellular pharmacokinetics are combined with the methods for estimation of drug-receptor binding energies for known and unknown receptors to provide a comprehensive quantitative approach to the construction of 结构活性关系. The emphasis is placed on understanding the principles of quantitative descriptions of absorption, 分布, metabolism and excretion and drug-receptor binding in terms of drug structure and properties. 预测药物理化性质的方法, 在药物开发中哪些是重要的, 进行了详细的分析. (3学分)

论文研究(PSC 761) 
这门课 consists of an independent research project which has been designed by the student, 咨询论文指导老师. 选出论文指导老师和论文委员会. The student will then develop a thesis proposal which will be approved by the thesis committee. 一旦在论文提案中描述的工作已经完成, 学生将撰写论文并进行答辩. 预计论文研究将在2-3个学期内完成. (1 - 8学分).

顶点石(PSC 750)
本课程只对非论文方向的学生开放. 顶点写作项目作为一个独立的学习课程运行. Students will select a topic in conjunction with the faculty instructor and prepare a written review of the existing scientific literature that is relevant to the chosen topic. The review should focus on a particular scientific problem that is actively being investigated and should define and discuss the scope of the problem, 这些办法所产生的实质性结果, 以及这些发现如何塑造了目前对这个问题的认识. (3学分) 先决条件:导师许可.